S-oxprenolol (ACM-002)

S-oxprenolol (ACM-002) is an anabolic-catabolic transforming agents1 and has a similar pharmacology to S-pindolol. 

Actimed has licensed the global rights to S-oxprenolol and retained rights in Amyotrophic Lateral Sclerosis (ALS), where loss of body mass and muscle wasting can impact survival. ALS is a devastating ultra-orphan disease of high, unmet medical need with mean survival of 3.5 years.

 In pre-clinical ALS models, S-oxprenolol has demonstrated significant benefits including slowing disease progression, improvement in survival, attenuation of muscle loss, motor neuron protection, reduction in loss of body mass and improvements in lean body mass2.

For cancer cachexia and other indications outside of ALS, Actimed has licensed the global rights to develop and commercialise S-oxprenolol to Faraday Pharmaceuticals.

 

References
1Pötsch MS, Tschirner A, Palus S, von Haehling S, Doehner W, Beadle J, Coats AJ, Anker SD, Springer J. The anabolic catabolic transforming agent (ACTA) espindolol increases muscle mass and decreases fat mass in old rats. J Cachexia Sarcopenia Muscle. 2014 Jun;5(2):149-58

2Suzuki et al, JCSM 2018; 9, 183-212. (Poster 5-17, page 200)