Cachexia (from the Greek word “kakos” meaning bad, and “hexis” meaning condition) is a wasting disease, associated with significant morbidity and mortality, accompanying a wide range of serious chronic illnesses.
It has been defined as weight loss, associated with a chronic underlying disease, of at least 5% in 12 months or less.
Cachexia is commonly associated with fatigue, loss of muscle strength, and fat tissue loss associated with a range of immune, neurohormonal, metabolic, and biochemical abnormalities. It is characteristically associated with negative protein loss, reduced food intake, and abnormal metabolism.
Evans WJ, Morley JE, Argilés J, Bales C, Baracos V, Guttridge D, et al. Cachexia: a new definition. Clin Nutr 2008; 27: 793–799.
Von Haehling S, Anker MS, Anker SD. Prevalence and clinical impact of cachexia in chronic illness in Europe, USA and Japan. J Cachexia Sarcopenia Muscle 2016; 7: 507–509.
Cachexia therapy / Unmet / Medical need / Cancer / Drug development / Patient's lives / Innovation